Large-Scale Investigation of Human TF-miRNA Relations Based on Coexpression Profiles
Joint Authors
Tsou, Ann-Ping
Chiang-Hsieh, Yi-Fan
Huang, Hsien-Da
Weng, Shun-Long
Chien, Chia-Hung
Chang, Wen-Chi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Noncoding, endogenous microRNAs (miRNAs) are fairly well known for regulating gene expression rather than protein coding.
Dysregulation of miRNA gene, either upregulated or downregulated, may lead to severe diseases or oncogenesis, especially when the miRNA disorder involves significant bioreactions or pathways.
Thus, how miRNA genes are transcriptionally regulated has been highlighted as well as target recognition in recent years.
In this study, a large-scale investigation of novel cis- and trans-elements was undertaken to further determine TF-miRNA regulatory relations, which are necessary to unravel the transcriptional regulation of miRNA genes.
Based on miRNA and annotated gene expression profiles, the term “coTFBS” was introduced to detect common transcription factors and the corresponding binding sites within the promoter regions of each miRNA and its coexpressed annotated genes.
The computational pipeline was successfully established to filter redundancy due to short sequence motifs for TFBS pattern search.
Eventually, we identified more convinced TF-miRNA regulatory relations for 225 human miRNAs.
This valuable information is helpful in understanding miRNA functions and provides knowledge to evaluate the therapeutic potential in clinical research.
Once most expression profiles of miRNAs in the latest database are completed, TF candidates of more miRNAs can be explored by this filtering approach in the future.
American Psychological Association (APA)
Chien, Chia-Hung& Chiang-Hsieh, Yi-Fan& Tsou, Ann-Ping& Weng, Shun-Long& Chang, Wen-Chi& Huang, Hsien-Da. 2014. Large-Scale Investigation of Human TF-miRNA Relations Based on Coexpression Profiles. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485926
Modern Language Association (MLA)
Chien, Chia-Hung…[et al.]. Large-Scale Investigation of Human TF-miRNA Relations Based on Coexpression Profiles. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-485926
American Medical Association (AMA)
Chien, Chia-Hung& Chiang-Hsieh, Yi-Fan& Tsou, Ann-Ping& Weng, Shun-Long& Chang, Wen-Chi& Huang, Hsien-Da. Large-Scale Investigation of Human TF-miRNA Relations Based on Coexpression Profiles. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485926