Molecular Signature in HCV-Positive Lymphomas

Abstract EN

Hepatitis C virus (HCV) is a positive, single-stranded RNA virus, which has been associated to different subtypes of B-cell non-Hodgkin lymphoma (B-NHL).

Cumulative evidence suggests an HCV-related antigen driven process in the B-NHL development.

The underlying molecular signature associated to HCV-related B-NHL has to date remained obscure.

In this review, we discuss the recent developments in this field with a special mention to different sets of genes whose expression is associated with BCR coupled to Blys signaling which in turn was found to be linked to B-cell maturation stages and NF-κb transcription factor.

Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified.