An Update on the Controversies in Anemia Management in Chronic Kidney Disease : Lessons Learned and Lost
Joint Authors
Teehan, Geoffrey
Benz, Robert L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs).
The optimal hemoglobin, in non-End Stage Renal Disease CKD, is controversial.
Methods.
We review three recent randomized trials in anemia in CKD: CHOIR, CREATE, and TREAT.
Results.
CHOIR (N=1432) was terminated early with more frequent death and cardiovascular outcomes in the higher Hb group (HR 1.34: 95% C.I.
1.03–1.74, P=.03).
CREATE (N=603) showed no difference in primary cardiovascular endpoints.
Stroke was more common in the higher Hb group (HR 1.92; 95% C.I.
1.38–2.68; P<.001) in TREAT (N=4038).
Conclusions.
There is no benefit to an Hb outside the 10–12 g/dL range in this population.
To avoid transfusions and improve Quality of Life, ESAs should be used cautiously, especially in patients with Diabetes, CKD, risk factors for stroke, and ESA resistance.
American Psychological Association (APA)
Teehan, Geoffrey& Benz, Robert L.. 2011. An Update on the Controversies in Anemia Management in Chronic Kidney Disease : Lessons Learned and Lost. Anemia،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-485967
Modern Language Association (MLA)
Teehan, Geoffrey& Benz, Robert L.. An Update on the Controversies in Anemia Management in Chronic Kidney Disease : Lessons Learned and Lost. Anemia No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-485967
American Medical Association (AMA)
Teehan, Geoffrey& Benz, Robert L.. An Update on the Controversies in Anemia Management in Chronic Kidney Disease : Lessons Learned and Lost. Anemia. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-485967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485967