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Updating the CTD Story : From Tail to Epic
Joint Authors
Bartkowiak, Bartlomiej
MacKellar, April L.
Greenleaf, Arno L.
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Eukaryotic RNA polymerase II (RNAPII) not only synthesizes mRNA but also coordinates transcription-related processes via its unique C-terminal repeat domain (CTD).
The CTD is an RNAPII-specific protein segment consisting of repeating heptads with the consensus sequence Y1S2P3T4S5P6S7 that has been shown to be extensively post-transcriptionally modified in a coordinated, but complicated, manner.
Recent discoveries of new modifications, kinases, and binding proteins have challenged previously established paradigms.
In this paper, we examine results and implications of recent studies related to modifications of the CTD and the respective enzymes; we also survey characterizations of new CTD-binding proteins and their associated processes and new information regarding known CTD-binding proteins.
Finally, we bring into focus new results that identify two additional CTD-associated processes: nucleocytoplasmic transport of mRNA and DNA damage and repair.
American Psychological Association (APA)
Bartkowiak, Bartlomiej& MacKellar, April L.& Greenleaf, Arno L.. 2011. Updating the CTD Story : From Tail to Epic. Genetics Research International،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-485974
Modern Language Association (MLA)
Bartkowiak, Bartlomiej…[et al.]. Updating the CTD Story : From Tail to Epic. Genetics Research International No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-485974
American Medical Association (AMA)
Bartkowiak, Bartlomiej& MacKellar, April L.& Greenleaf, Arno L.. Updating the CTD Story : From Tail to Epic. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-485974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485974