![](/images/graphics-bg.png)
The Mechanism of Budding of Retroviruses from Cell Membranes
Joint Authors
Pincetic, Andrew
Leis, Jonathan
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Retroviruses have evolved a mechanism for the release of particles from the cell membrane that appropriates cellular protein complexes, referred to as ESCRT-I, -II, -III, normally involved in the biogenesis of multivesicular bodies.
Three different classes of late assembly (L) domains encoded in Gag, with core sequences of PPXY, PTAP, and YPXL, recruit different components of the ESCRT machinery to form a budding complex for virus release.
Here, we highlight recent progress in identifying the role of different ESCRT complexes in facilitating budding, ubiquitination, and membrane targeting of avian sarcoma and leukosis virus (ASLV) and human immunodeficiency virus, type 1 (HIV-1).
These findings show that retroviruses may adopt parallel budding pathways by recruiting different host factors from common cellular machinery for particle release.
American Psychological Association (APA)
Pincetic, Andrew& Leis, Jonathan. 2009. The Mechanism of Budding of Retroviruses from Cell Membranes. Advances in Virology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-485996
Modern Language Association (MLA)
Pincetic, Andrew& Leis, Jonathan. The Mechanism of Budding of Retroviruses from Cell Membranes. Advances in Virology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-485996
American Medical Association (AMA)
Pincetic, Andrew& Leis, Jonathan. The Mechanism of Budding of Retroviruses from Cell Membranes. Advances in Virology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-485996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485996