Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
Joint Authors
Mitchell, Sarah J.
Kane, Alice E.
Hilmer, Sarah N.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood.
However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults.
Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity.
Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults.
Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity.
Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults.
Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit.
American Psychological Association (APA)
Mitchell, Sarah J.& Kane, Alice E.& Hilmer, Sarah N.. 2011. Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol. Current Gerontology and Geriatrics Research،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-486017
Modern Language Association (MLA)
Mitchell, Sarah J.…[et al.]. Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol. Current Gerontology and Geriatrics Research No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-486017
American Medical Association (AMA)
Mitchell, Sarah J.& Kane, Alice E.& Hilmer, Sarah N.. Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol. Current Gerontology and Geriatrics Research. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-486017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486017