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Bacteriophage Administration Reduces the Concentration of Listeria monocytogenes in the Gastrointestinal Tract and Its Translocation to Spleen and Liver in Experimentally Infected Mice
Joint Authors
Visone, Lee
Mai, Volker
Abuladze, Tamar
Sulakvelidze, Alexander
Ukhanova, Maria
Source
International Journal of Microbiology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
To investigate the efficacy of phage supplementation in reducing pathogen numbers, mice were treated via oral gavage with a Listeria monocytogenes phage preparation (designated ListShield) before being orally infected with L.
monocytogenes.
The concentrations of L.
monocytogenes in the liver, spleen, and intestines were significantly lower (P<.05) in the phage-treated than in the control mice.
Phage and antibiotic treatments were similarly effective in reducing the levels of L.
monocytogenes in the internal organs of the infected mice.
However, the significant weight loss detected in the control and antibiotic-treated groups was not observed in the infected, ListShield-treated mice.
Long-term (90 days), biweekly treatment of uninfected mice with ListShield did not elicit detectable changes in the microbiota of their large intestines or deleterious changes in their health.
Our data support the potential feasibility of using bacteriophages to control proliferation of L.
monocytogenes in mice without affecting commensal microbiota composition.
American Psychological Association (APA)
Mai, Volker& Ukhanova, Maria& Visone, Lee& Abuladze, Tamar& Sulakvelidze, Alexander. 2010. Bacteriophage Administration Reduces the Concentration of Listeria monocytogenes in the Gastrointestinal Tract and Its Translocation to Spleen and Liver in Experimentally Infected Mice. International Journal of Microbiology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-486025
Modern Language Association (MLA)
Mai, Volker…[et al.]. Bacteriophage Administration Reduces the Concentration of Listeria monocytogenes in the Gastrointestinal Tract and Its Translocation to Spleen and Liver in Experimentally Infected Mice. International Journal of Microbiology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-486025
American Medical Association (AMA)
Mai, Volker& Ukhanova, Maria& Visone, Lee& Abuladze, Tamar& Sulakvelidze, Alexander. Bacteriophage Administration Reduces the Concentration of Listeria monocytogenes in the Gastrointestinal Tract and Its Translocation to Spleen and Liver in Experimentally Infected Mice. International Journal of Microbiology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-486025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486025