Coordination Chemistry of Polyaromatic Thiosemicarbazones 2 : Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone
Joint Authors
Seeram, Navindra P.
Gonzalez-Sarrías, Antonio
Beckford, Floyd A.
Mbarushimana, P. Canisius
LeBlanc, Marc-Andre
Source
International Journal of Inorganic Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A novel thiosemicarbazone from 2-acetonaphthone (represented as acnTSC) has been synthesized and its basic coordination chemistry with zinc(II), cobalt(II), and copper(II) explored.
The complexes were characterized by elemental analysis and various spectroscopic techniques and are best formulated as [M(acnTSC)2Cl2] with the metal likely in an octahedral environment.
The anticancer activity of the complexes was determined against a panel of human colon cancer cells (HCT-116 and Caco-2).
The compounds bind to DNA via an intercalative mode with binding constants of 9.7×104 M-1, 1.8×105 M-1, and 9.5×104 M-1 for the zinc, cobalt, and copper complexes, respectively.
American Psychological Association (APA)
LeBlanc, Marc-Andre& Gonzalez-Sarrías, Antonio& Beckford, Floyd A.& Mbarushimana, P. Canisius& Seeram, Navindra P.. 2011. Coordination Chemistry of Polyaromatic Thiosemicarbazones 2 : Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone. International Journal of Inorganic Chemistry،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486067
Modern Language Association (MLA)
LeBlanc, Marc-Andre…[et al.]. Coordination Chemistry of Polyaromatic Thiosemicarbazones 2 : Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone. International Journal of Inorganic Chemistry No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-486067
American Medical Association (AMA)
LeBlanc, Marc-Andre& Gonzalez-Sarrías, Antonio& Beckford, Floyd A.& Mbarushimana, P. Canisius& Seeram, Navindra P.. Coordination Chemistry of Polyaromatic Thiosemicarbazones 2 : Synthesis and Biological Activity of Zinc, Cobalt, and Copper Complexes of 1-(Naphthalene-2-yl)ethanone Thiosemicarbazone. International Journal of Inorganic Chemistry. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-486067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486067
