Pediatric Selective IgM Immunodeficiency
Joint Authors
Dvorin, Donald J.
Belecanech, George A.
Goldstein, Marc F.
Goldstein, Alex L.
Shamir, Kfir
Dunsky, Eliot H.
Source
Clinical and Developmental Immunology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID).
Previously published pediatric cases and 2 new cases are reviewed.
Methods.
English literature from PubMed and references from relevant articles were reviewed.
Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed.
Results.
Forty-nine reported cases of SIgMID presented with respiratory infections (77.6%), gastrointestinal disease (16.3%), skin disease (12.2%), and meningitis (8.2%).
Mean serum IgM level was 16.5±13.8 mg/dL.
Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%) presenting with asthma, vasomotor rhinitis, and recurrent respiratory infections.
In the 51 cases reported, none developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia; four fatalities were reported.
Conclusions.
The prevalence of SIgMID in our pediatric population was 0.03%.
In general, respiratory infections are the common comorbid conditions.
Death and autoimmune disease are uncommon complications of pediatric SIgMID.
American Psychological Association (APA)
Goldstein, Marc F.& Goldstein, Alex L.& Dunsky, Eliot H.& Dvorin, Donald J.& Belecanech, George A.& Shamir, Kfir. 2008. Pediatric Selective IgM Immunodeficiency. Clinical and Developmental Immunology،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-486081
Modern Language Association (MLA)
Goldstein, Marc F.…[et al.]. Pediatric Selective IgM Immunodeficiency. Clinical and Developmental Immunology No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-486081
American Medical Association (AMA)
Goldstein, Marc F.& Goldstein, Alex L.& Dunsky, Eliot H.& Dvorin, Donald J.& Belecanech, George A.& Shamir, Kfir. Pediatric Selective IgM Immunodeficiency. Clinical and Developmental Immunology. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-486081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486081
