In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus
Joint Authors
Touil-Boukoffa, Chafia
Zeghir-Bouteldja, Razika
Aitaissa, Saliha
Amri, Manel
Mezioug, Dalila
Bouaziz, Samia
Source
Journal of Parasitology Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hydatidosis is characterized by the long-term coexistence of larva Echinococcus granulosus and its host without effective rejection.
Previous studies demonstrated nitric oxide (NO) production (in vivo and in vitro) during hydatidosis.
In this study, we investigated the direct in vitro effects of NO species: nitrite (NO2−), nitrate (NO3−) and peroxynitrite (ONOO−) on protoscolices (PSCs) viability and hydatid cyst layers integrity for 24 hours and 48 hours.
Our results showed protoscolicidal activity of NO2− and ONOO− 24 hours and 3 hours after treatment with 320 μM and 80 μM respectively.
Degenerative effects were observed on germinal and laminated layers.
The comparison of the in vitro effects of NO species on the PSCs viability indicated that ONOO− is more cytotoxic than NO2−.
In contrast, NO3− has no effect.
These results suggest possible involvement of NO2− and ONOO− in antihydatic action and point the efficacy of these metabolites as scolicidal agents.
American Psychological Association (APA)
Zeghir-Bouteldja, Razika& Amri, Manel& Aitaissa, Saliha& Bouaziz, Samia& Mezioug, Dalila& Touil-Boukoffa, Chafia. 2009. In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus. Journal of Parasitology Research،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-486084
Modern Language Association (MLA)
Zeghir-Bouteldja, Razika…[et al.]. In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus. Journal of Parasitology Research No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-486084
American Medical Association (AMA)
Zeghir-Bouteldja, Razika& Amri, Manel& Aitaissa, Saliha& Bouaziz, Samia& Mezioug, Dalila& Touil-Boukoffa, Chafia. In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus. Journal of Parasitology Research. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-486084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486084