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Diagnosis of Non-ST-Elevation Acute Coronary Syndrome by the Measurement of Heart-Type Fatty Acid Binding Protein in Serum : A Prospective Case Control Study
Joint Authors
Satish, Oruganti Sai
Chandran, Priscilla Abraham
Mohammed, Noorjahan
Wani, Basharat Ara
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A prospective case control study was undertaken to evaluate the diagnostic performance of serum heart-type fatty acid binding protein (HFABP) in comparison to cardiac TnT and TnI in 33 patients admitted with chest pain, diagnosed as NSTE-ACS (non ST elevation acute coronary syndrome) and 22 healthy controls.
Area under the receiver operating curve (AUC) was highest for H-FABP (AUC 0.79; 95% CI 0.66–0.89) versus cTnI (AUC 0.73; 95% CI 0.59–0.84) and cTnT (AUC 0.71; 95% CI 0.57–0.83).
The H-FABP level above 6.5 ng/mL showed 56.7% (CI 37.4–74.5) sensitivity, 0.5 (95% CI 0.3–0.7) negative likelihood ratio (−LR), 100% (CI 84.6–100.0) specificity, and 100% (CI 79.4–100.0) positive predictive value (PPV), 62.9% (CI 44.9–78.5) negative predictive value (NPV).
cTnI level above 0.009 μg/L had 40% (CI 22.7–59.4) sensitivity, 0.6 (95% CI 0.4–0.8) −LR, 100% (CI 84.6–100.0) specificity, 100% (CI 73.5–100.0) PPV, and 55% (CI 38.5–70.7) NPV.
cTnT showed 46.7% (CI 28.3–65.7) sensitivity, 0.5 (95% CI 0.4–0.7) −LR, 100% (CI 84.6–100.0) specificity, 100% (CI 76.8–100.0) PPV, and 57.9% (CI 40.8–73.7) NPV at level above 9 μg/L.
+LR were 12.5 (95% CI 1.8–86.8), 1.7 (95% CI 1.0–3.0), and 1.2 (95% CI 0.8–1.9) for H-FABP, cTnI, and cTnT respectively.
In conclusion measurement of H-FABP is a valuable tool in the early diagnosis of patients with chest pain (6–8 hrs) and seems to be a preferred biomarker in the differential diagnosis of NSTE-ACS.
More studies are needed to determine whether serum H-FABP further improves diagnostic performance.
American Psychological Association (APA)
Chandran, Priscilla Abraham& Wani, Basharat Ara& Satish, Oruganti Sai& Mohammed, Noorjahan. 2014. Diagnosis of Non-ST-Elevation Acute Coronary Syndrome by the Measurement of Heart-Type Fatty Acid Binding Protein in Serum : A Prospective Case Control Study. Journal of Biomarkers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-486086
Modern Language Association (MLA)
Chandran, Priscilla Abraham…[et al.]. Diagnosis of Non-ST-Elevation Acute Coronary Syndrome by the Measurement of Heart-Type Fatty Acid Binding Protein in Serum : A Prospective Case Control Study. Journal of Biomarkers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-486086
American Medical Association (AMA)
Chandran, Priscilla Abraham& Wani, Basharat Ara& Satish, Oruganti Sai& Mohammed, Noorjahan. Diagnosis of Non-ST-Elevation Acute Coronary Syndrome by the Measurement of Heart-Type Fatty Acid Binding Protein in Serum : A Prospective Case Control Study. Journal of Biomarkers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-486086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486086