Mitotane-Induced Hyperlipidemia : A Retrospective Cohort Study
Joint Authors
Hernandez, Mike
Vassilopoulou-Sellin, Rena
Jiménez, Camilo
Deniz, Ferhat
Bazerbashi, Hadil
Shawa, Hassan
Habra, Mouhammed Amir
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Limited data are available about mitotane-nduced hyperlipidemia.
We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of lipid changes.
At baseline, the mean levels of HDL-c, LDL-c, and triglycerides were 53.3 mg/dL, 114.4 mg/dL, and 149 mg/dL, respectively.
HDL-c, LDL-c, and triglyceride concentrations significantly increased with mitotane therapy to a mean HDL peak (HDL-P) of 86.3 mg/dL (P<0.001), a mean LDL peak of 160.1 mg/dL (P<0.001), and a mean triglyceride peak (Tg-P) of 216.7 mg/dL (P=0.042).
HDL-P positively correlated with mitotane concentration (r=0.52,P<0.001), while LDL-P levels and Tg-P did not.
Gender, body mass index, cortisol overproduction, baseline levels of HDL-c, and triglyceride did not predict change in HDL-c.
Similar changes were noticed in subgroup analysis after excluding patients who were using lipid-lowering agents.
In conclusion, in ACC patients, mitotane caused significant increases in HDL-c that may counteract the deleterious atherosclerotic effects of LDL-c and Tg rise.
Understanding the mechanism of HDL change may lead to the discovery of novel HDL-c-elevating drugs.
American Psychological Association (APA)
Shawa, Hassan& Deniz, Ferhat& Bazerbashi, Hadil& Hernandez, Mike& Vassilopoulou-Sellin, Rena& Jiménez, Camilo…[et al.]. 2013. Mitotane-Induced Hyperlipidemia : A Retrospective Cohort Study. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486089
Modern Language Association (MLA)
Shawa, Hassan…[et al.]. Mitotane-Induced Hyperlipidemia : A Retrospective Cohort Study. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-486089
American Medical Association (AMA)
Shawa, Hassan& Deniz, Ferhat& Bazerbashi, Hadil& Hernandez, Mike& Vassilopoulou-Sellin, Rena& Jiménez, Camilo…[et al.]. Mitotane-Induced Hyperlipidemia : A Retrospective Cohort Study. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486089