Effects of Electroacupuncture on PGC-1α Expression in Brown Adipose Tissue
Joint Authors
Wu, Hui
Du, Hongyin
Zhou, Cuisong
Shan, Tianyue
Wu, Zhenjue
Xu, Bin
Zhang, Yubin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The inducible coactivator PGC-1α plays master regulator in mitochondrial biogenesis and thermogenesis in brown adipose tissues (BATs).
BAT is a natural antiobesity organ which dissipates chemical energy in the form of heat through specialized mitochondrial protein UCP-1.
Eletroacupuncture (EA) has been widely used as an alternative treatment for obesity and its related disorders such as type 2 diabetes.
The molecular mechanism of electroacupuncture on treatment of obesity is still unclear.
We hypothesized that electroacupuncture induced PGC-1α expression to increase the energy expenditure in BAT.
Rats were randomly divided into control group and electroacupuncture treatment group.
We investigated the effects of electroacupuncture at Zusanli (ST36) acupoint on the expressions of PGC-1α and its associated genes in the BAT of rats using real-time PCR and western blotting.
We found that electroacupuncture effectively induces the expression of PGC-1α and UCP-1 by 4-fold and 5-fold in the BAT of rats, respectively.
Our results indicated that the molecular mechanism of electroacupuncture for the treatment of obesity may be, or at least partially, through induction of both PGC-1α and UCP-1 expressions to increase energy expenditure in BAT.
American Psychological Association (APA)
Du, Hongyin& Zhou, Cuisong& Wu, Hui& Shan, Tianyue& Wu, Zhenjue& Xu, Bin…[et al.]. 2013. Effects of Electroacupuncture on PGC-1α Expression in Brown Adipose Tissue. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486102
Modern Language Association (MLA)
Du, Hongyin…[et al.]. Effects of Electroacupuncture on PGC-1α Expression in Brown Adipose Tissue. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-486102
American Medical Association (AMA)
Du, Hongyin& Zhou, Cuisong& Wu, Hui& Shan, Tianyue& Wu, Zhenjue& Xu, Bin…[et al.]. Effects of Electroacupuncture on PGC-1α Expression in Brown Adipose Tissue. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486102