Sex Steroids Effects on the Molting Process of the Helminth Human Parasite Trichinella spiralis
Joint Authors
Nava-Castro, Karen
Sánchez-Acosta, Ana Gabriela
Morales-Montor, Jorge
Hernández-Bello, Romel
Ramirez-Nieto, Ricardo
Pavon, Lenin
Muñiz-Hernández, Saé
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We evaluated the in vitro effects of estradiol, progesterone, and testosterone on the molting process, which is the initial and crucial step in the development of the muscular larvae (ML or L1) to adult worm.
Testosterone had no significative effect on the molting rate of the parasite, however, progesterone decreased the molting rate about a 50% in a concentration- and time-independent pattern, while estradiol had a slight effect (10%).
The gene expression of caveolin-1, a specific gene used as a marker of parasite development, showed that progesterone and estradiol downregulated its expression, while protein expression was unaffected.
By using flow citometry, a possible protein that is recognized by a commercial antiprogesterone receptor antibody was detected.
These findings may have strong implications in the host-parasite coevolution, in the sex-associated susceptibility to this infection and could point out to possibilities to use antihormones to inhibit parasite development.Erratum to “Sex Steroids Effects on the Molting Process of the Helminth Human Parasite Trichinella spiralis”dx.doi.org/10.1155/2013/586951
American Psychological Association (APA)
Hernández-Bello, Romel& Ramirez-Nieto, Ricardo& Muñiz-Hernández, Saé& Nava-Castro, Karen& Pavon, Lenin& Sánchez-Acosta, Ana Gabriela…[et al.]. 2011. Sex Steroids Effects on the Molting Process of the Helminth Human Parasite Trichinella spiralis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-486129
Modern Language Association (MLA)
Hernández-Bello, Romel…[et al.]. Sex Steroids Effects on the Molting Process of the Helminth Human Parasite Trichinella spiralis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-486129
American Medical Association (AMA)
Hernández-Bello, Romel& Ramirez-Nieto, Ricardo& Muñiz-Hernández, Saé& Nava-Castro, Karen& Pavon, Lenin& Sánchez-Acosta, Ana Gabriela…[et al.]. Sex Steroids Effects on the Molting Process of the Helminth Human Parasite Trichinella spiralis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-486129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486129