Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer
Joint Authors
Milecki, Piotr
Baczyk, Maciej
Kwias, Zbigniew
Martenka, Piotr
Antczak, Andrzej
Skowronek, Janusz
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To study whether use of neoadjuvant androgen deprivation therapy (N-ADT) combined with whole pelvic radiotherapy (WPRT) for high-risk prostate cancer patients was associated with survival benefit over prostate radiotherapy (PORT) only.
Material and Methods.
Between 1999 and 2004, 162 high-risk prostate cancer patients were treated with radiotherapy combined with long-term androgen deprivation therapy (L-ADT).
Patients were prospectively assigned into two groups: A (N-ADT + WPRT + L-ADT) n = 70 pts, B (PORT + L-ADT) n = 92 pts.
Results.
The 5-year actuarial overall survival (OS) rates were 89% for A and 78% for B (P = .13).
The 5-year actuarial cause specific survival (CSS) rates were A = 90% and B = 79% (P = .01).
Biochemical progression-free survival (bPFS) rates were 52% versus 40% (P = .07), for groups A and B, respectively.
Conclusions.
The WPRT combined with N-ADT compared to PORT for high-risk patients resulted in improvement in CSS and bPFS; however no OS benefit was observed.
American Psychological Association (APA)
Milecki, Piotr& Baczyk, Maciej& Skowronek, Janusz& Antczak, Andrzej& Kwias, Zbigniew& Martenka, Piotr. 2009. Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-486132
Modern Language Association (MLA)
Milecki, Piotr…[et al.]. Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-486132
American Medical Association (AMA)
Milecki, Piotr& Baczyk, Maciej& Skowronek, Janusz& Antczak, Andrzej& Kwias, Zbigniew& Martenka, Piotr. Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-486132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486132