A Comparative Systematic Review of the Optimal CD4 Cell Count Threshold for HIV Treatment Initiation
Joint Authors
Mitchell-Fearon, Kathryn
Ogunmoroti, Oluseye
Olubajo, Babatunde
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
HIV infection is no longer characterized by high morbidity, rapid progression to AIDS, and death as when the infection was first identified.
While anti-retroviral drugs have improved the outcome of AIDS patients, clinical research on the appropriate time to initiate therapy continues to evolve.
Optimal therapy initiation would maximize the benefits of these drugs, while minimizing side effects and drug resistance.
Recent 2013 WHO guidelines changed HIV therapy initiation from 350 cells/μL to 500 cells/μL.
This systematic review provides an evidence-based comparison of starting treatment at >500 cells/μL with starting treatment at the range between 350 cells/μL and 500 cells/μL.
An 11% increase in risk was detected from initiation therapy at the 350–500 cells/μL range (0.37 [0.26, 0.53]), when compared with starting treatment before 500 cells/μL (0.33 [0.22, 0.48]).
Most individual study comparisons showed a benefit for starting treatment at 500 cells/μL in comparison with starting at the 350–500 cells/μL range with risks ranging from 19% to 300%, though a number of comparisons were not statistically significant.
Overall, the study provides evidence based support for initiating anti retroviral therapy at cell counts >500 cells/μL wherever possible to prevent AIDS mortality and morbidity.
American Psychological Association (APA)
Olubajo, Babatunde& Mitchell-Fearon, Kathryn& Ogunmoroti, Oluseye. 2014. A Comparative Systematic Review of the Optimal CD4 Cell Count Threshold for HIV Treatment Initiation. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-486148
Modern Language Association (MLA)
Olubajo, Babatunde…[et al.]. A Comparative Systematic Review of the Optimal CD4 Cell Count Threshold for HIV Treatment Initiation. Interdisciplinary Perspectives on Infectious Diseases No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-486148
American Medical Association (AMA)
Olubajo, Babatunde& Mitchell-Fearon, Kathryn& Ogunmoroti, Oluseye. A Comparative Systematic Review of the Optimal CD4 Cell Count Threshold for HIV Treatment Initiation. Interdisciplinary Perspectives on Infectious Diseases. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-486148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486148