The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
Joint Authors
Cutuli, Salvatore Lucio
Pennisi, Mariano Alberto
Antonelli, Massimo
De Pascale, Gennaro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU).
Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest.
Particularly when adaptive immune system is compromised or immature, innate immunity plays a key role in the immediate defense against invasive pathogens.
Mannose-binding lectin (MBL) is a serum protein that recognizes a wide range of pathogenic microorganisms and activates complement cascade via the antibody-independent pathway.
More than 30% of humans harbor mutations in MBL gene (MBL2) resulting in reduced plasmatic levels and activity.
Increased risk of infection acquisition has been largely documented in MBL-deficient patients, but the real impact of this form of innate immunosuppression upon clinical outcome is not clear.
In critically ill patients higher incidence and worse prognosis of severe sepsis/septic shock appear to be associated with low-producers haplotypes.
However an excess of MBL activation might be also harmful due to the possibility of an unbalanced proinflammatory response and an additional host injury.
Strategies of replacement therapies in critically ill patients with severe infections are under investigation but still far to be applied in clinical practice.
American Psychological Association (APA)
De Pascale, Gennaro& Cutuli, Salvatore Lucio& Pennisi, Mariano Alberto& Antonelli, Massimo. 2013. The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486159
Modern Language Association (MLA)
De Pascale, Gennaro…[et al.]. The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-486159
American Medical Association (AMA)
De Pascale, Gennaro& Cutuli, Salvatore Lucio& Pennisi, Mariano Alberto& Antonelli, Massimo. The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486159