Lysophosphatidylcholine : A Novel Modulator of Trypanosoma cruzi Transmission
Joint Authors
Silva-Cardoso, Livia
Atella, Georgia C.
Carneiro, Alan B.
Silva-Neto, Mário A. C.
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque.
Such molecule is also present in saliva and feces of the hematophagous organism Rhodnius prolixus, a triatominae bug vector of Chagas disease.
We have recently demonstrated that LPC is a modulator of Trypanosoma cruzi transmission.
It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection.
Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion.
Finally, LPC inhibits NO production by macrophages stimulated by live T.
cruzi, and thus interferes with the immune system of the vertebrate host.
In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease.
American Psychological Association (APA)
Silva-Neto, Mário A. C.& Carneiro, Alan B.& Silva-Cardoso, Livia& Atella, Georgia C.. 2011. Lysophosphatidylcholine : A Novel Modulator of Trypanosoma cruzi Transmission. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486166
Modern Language Association (MLA)
Silva-Neto, Mário A. C.…[et al.]. Lysophosphatidylcholine : A Novel Modulator of Trypanosoma cruzi Transmission. Journal of Parasitology Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-486166
American Medical Association (AMA)
Silva-Neto, Mário A. C.& Carneiro, Alan B.& Silva-Cardoso, Livia& Atella, Georgia C.. Lysophosphatidylcholine : A Novel Modulator of Trypanosoma cruzi Transmission. Journal of Parasitology Research. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486166