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Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy
Joint Authors
Neurath, Markus F.
Zirlik, Sabine
Hildner, Kai M.
Fuchs, Florian S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
The early diagnosis of malignant and premalignant changes of the bronchial mucosa remains a major challenge during bronchoscopy.
Intravital staining techniques are not new.
Previous small case series suggested that analysis of the bronchial mucosal surface using chromoendoscopy allows a prediction between neoplastic and nonneoplastic lesions.
Objectives.
The aim of the present study was to evaluate chromobronchoscopy as a method to identify malignant and premalignant lesions in the central airways in a prospective manner.
Methods.
In 26 patients we performed chromoendoscopy with 0.1% methylene blue during ongoing flexible white light bronchoscopy.
Circumscribed lesions in central airways were further analyzed by biopsies and histopathologic examination.
Results.
In the majority of cases neither flat nor polypoid lesions in the central airways were stained by methylene blue.
In particular, exophytic growth of lung cancer did not show any specific pattern in chromobronchoscopy.
However, a specific dye staining was detected in one case where exophytic growth of metastatic colorectal cancer was present in the right upper lobe.
In two other cases, a circumscribed staining was noted in unsuspicious mucosa.
But histology revealed inflammation only.
Conclusions.
In contrast to previous studies, the present findings clearly indicate that chromobronchoscopy is not useful for early detection of malignant or premalignant lesions of the central airways.
American Psychological Association (APA)
Zirlik, Sabine& Hildner, Kai M.& Neurath, Markus F.& Fuchs, Florian S.. 2012. Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-486170
Modern Language Association (MLA)
Zirlik, Sabine…[et al.]. Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy. The Scientific World Journal No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-486170
American Medical Association (AMA)
Zirlik, Sabine& Hildner, Kai M.& Neurath, Markus F.& Fuchs, Florian S.. Methylene Blue-Aided In Vivo Staining of Central Airways during Flexible Bronchoscopy. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-486170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486170