Role of GLP-1 in the Hypoglycemic Effects of Wild Bitter Gourd
Joint Authors
Chin Hsu,
Huang, Ting-ni
Pai, Yi-Ping
Lu, Kan-Ni
Huang, Ching-jang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study aimed to examine the role of GLP-1 in the hypoglycemic activity of wild bitter gourd (Momordica charantia L., BG).
In vitro, the GLP-1 secretion in STC-1, a murine enteroendocrine cell line, was dose dependently stimulated by water extract (WE), its fractions (WEL, >3 kD and WES, <3 kD), and a bitter compounds-rich fraction of BG.
These stimulations were partially inhibited by probenecid, a bitter taste receptor inhibitor, and by U-73122, a phospholipase Cβ2 inhibitor.
These results suggested that the stimulation might involve, at least in part, certain bitter taste receptors and/or PLCβ2-signaling pathway.
Two cucurbitane triterpenoids isolated from BG, 19-nor-cucurbita-5(10),6,8,22-(E),24-pentaen-3β-ol, and 5β,19-epoxycucurbita-6,24-diene-3β,23ξ-diol (karavilagenine E,) showed relative high efficacy in the stimulation.
In vivo, mice fed BG diet showed higher insulinogenic index in an oral glucose tolerance test.
A single oral dose of WE or WES pretreatment significantly improved intraperitoneal glucose tolerance.
A single oral dose of WES significantly decreased glucose and increased insulin and GLP-1 in serum after 30 min.
This acute hypoglycemic effect of WES was abolished by pretreatment with exendin-9, a GLP-1 receptor antagonist.
Our data provide evidence that BG stimulates GLP-1 secretion which contributes, at least in part, to the antidiabetic activity of BG through an incretin effect.
American Psychological Association (APA)
Huang, Ting-ni& Lu, Kan-Ni& Pai, Yi-Ping& Chin Hsu, & Huang, Ching-jang. 2013. Role of GLP-1 in the Hypoglycemic Effects of Wild Bitter Gourd. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-486172
Modern Language Association (MLA)
Huang, Ting-ni…[et al.]. Role of GLP-1 in the Hypoglycemic Effects of Wild Bitter Gourd. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-486172
American Medical Association (AMA)
Huang, Ting-ni& Lu, Kan-Ni& Pai, Yi-Ping& Chin Hsu, & Huang, Ching-jang. Role of GLP-1 in the Hypoglycemic Effects of Wild Bitter Gourd. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-486172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486172