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Metabonomics Study of Essential Hypertension and Its Chinese Medicine Subtypes by Using Gas Chromatography-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy
Joint Authors
Jiang, Haiqiang
Qi, Dongmei
Nie, Lei
Qu, Zhengjun
Zhou, Honglei
Zhang, Yunhui
Li, Yunlun
Xie, Jun
Lin, Jiamao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A metabonomic study was performed to investigate the metabolic mechanism of essential hypertension and its Chinese medicine subtypes, including “Yin-deficiency and Yang-hyperactivity syndrome” (YDYHS) and “Yin-Yang deficiency syndrome” (YYDS).
Plasma samples from 22 healthy volunteers, 31 hypertensive patients with YDYHS, and 29 hypertensive patients with YYDS were analyzed by 1H-NMR spectroscopy and gas chromatography coupled with mass spectrometry (GC-MS).
The three groups were distinctly classified by principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA).
According to identified biomarkers and their related pathways, abnormal glucose metabolism might be the main common pathway from YDYHS to YYDS, and sympathetic nervous system activation would play an important role in the pathogenesis of YDYHS, while a low metabolic rate usually occurred in YYDS.
American Psychological Association (APA)
Li, Yunlun& Nie, Lei& Jiang, Haiqiang& Lin, Jiamao& Zhou, Honglei& Xie, Jun…[et al.]. 2013. Metabonomics Study of Essential Hypertension and Its Chinese Medicine Subtypes by Using Gas Chromatography-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486174
Modern Language Association (MLA)
Li, Yunlun…[et al.]. Metabonomics Study of Essential Hypertension and Its Chinese Medicine Subtypes by Using Gas Chromatography-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-486174
American Medical Association (AMA)
Li, Yunlun& Nie, Lei& Jiang, Haiqiang& Lin, Jiamao& Zhou, Honglei& Xie, Jun…[et al.]. Metabonomics Study of Essential Hypertension and Its Chinese Medicine Subtypes by Using Gas Chromatography-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486174