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Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKLRANKOPG Signal Pathway
Joint Authors
Zhan, Hongsheng
Liu, Chunfang
Xu, Ying
Chen, Weiheng
Pang, Jian
Zhang, Yanqiong
Zhu, Liuluan
Lu, Ai-ping
Kong, Xiangying
Lin, Na
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Focal bone destruction within inflamed joints is the most specific hallmark of rheumatoid arthritis (RA).
Our previous study indicated that the therapeutic efficiency of triptolide in RA may be due partially to its chondroprotective and anti-inflammatory effects.
However, its roles in bone destruction are still unclear.
In this study, our data firstly showed the therapeutic effects of triptolide on severity of arthritis and arthritis progression in collagen-induced arthritis (CIA) mice.
Then, by micro-CT quantification, triptolide treatment significantly increased bone mineral density, bone volume fraction, and trabecular thickness and decreased trabecular separation of inflamed joints.
Interestingly, triptolide treatment could prevent the bone destruction by reducing the number of osteoclasts in inflamed joints, reducing the expression of receptor activator of NF-κB (RANK) ligand (RANKL) and RANK, increasing the expression of osteoprotegerin (OPG), at both mRNA and protein levels, and decreasing the ratio of RANKL to OPG in sera and inflamed joints of CIA mice, which were further confirmed in the coculture system of human fibroblast-like synovial and peripheral blood mononuclear cells.
These findings offer the convincing evidence for the first time that triptolide may attenuate RA partially by preventing the bone destruction and inhibit osteoclast formation by regulating RANKL/RANK/OPG signal pathway.
American Psychological Association (APA)
Liu, Chunfang& Zhang, Yanqiong& Kong, Xiangying& Zhu, Liuluan& Pang, Jian& Xu, Ying…[et al.]. 2013. Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKLRANKOPG Signal Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-486189
Modern Language Association (MLA)
Liu, Chunfang…[et al.]. Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKLRANKOPG Signal Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-486189
American Medical Association (AMA)
Liu, Chunfang& Zhang, Yanqiong& Kong, Xiangying& Zhu, Liuluan& Pang, Jian& Xu, Ying…[et al.]. Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKLRANKOPG Signal Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-486189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486189