In Silico Studies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone)
Joint Authors
Sahu, Sunil Kumar
Kandasamy, Saravanakumar
Kandasamy, Kathiresan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This work was to find out the dominant secondary metabolites derived from the fungus Trichoderma and to test them against skin cancer protein.
The metabolites were extracted in 80% methanol from the fungal biomass of Trichoderma isolated from mangrove sediment.
The crude methanol extract was purified and analysed for the secondary metabolites by GC-MS.
Three predominant compounds (heptadecanoic acid, 16 methyl-, methyl ester; 9,12-octadecadienoic acid; cis-9-octadecenoic acid) identified in the extracts were screened against the skin cancer protein (Hsp90) by in-silico docking method.
Of the compounds, heptadecanoic acid, 16 methyl, methyl ester was the most potent having the docking score of -11.4592 Kcal/mol.
This value was better than the standard drug “dyclonine”.
This work recommends the heptadecanoic acid, 16 methyl, methyl ester for further in vitro and in vivo studies towards its development as anticancer drug.
American Psychological Association (APA)
Kandasamy, Saravanakumar& Sahu, Sunil Kumar& Kandasamy, Kathiresan. 2012. In Silico Studies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone). ISRN Dermatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-486202
Modern Language Association (MLA)
Kandasamy, Saravanakumar…[et al.]. In Silico Studies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone). ISRN Dermatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-486202
American Medical Association (AMA)
Kandasamy, Saravanakumar& Sahu, Sunil Kumar& Kandasamy, Kathiresan. In Silico Studies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone). ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-486202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486202