Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease
Joint Authors
Galle, Peter R.
Thüroff, Joachim W.
Schadt, Jörg
Gockel, Ines
Graf, Claudine
Brenner, Walburgis
Schimanski, Carl C.
Moehler, Markus
Berger, Martin R.
Wehler, Thomas C.
Biesterfeld, Stefan
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape.
In different tumor entities, the level of chemokine receptor CXCR4 expression has been linked with tumor progression and decreased survival.
The aim of this study was to evaluate the influence of CXCR4 expression on the progression of human renal cell carcinoma.
CXCR4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients.
Intensity of CXCR4 expression was correlated with both tumor and patient characteristics.
Human renal cell carcinoma revealed variable intensities of CXCR4 expression.
Strong CXCR4 expression of renal cell carcinoma was significantly associated with advanced T-status (P=.039), tumor dedifferentiation (P = .0005), and low hemoglobin (P = .039).
In summary, strong CXCR4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.
American Psychological Association (APA)
Wehler, Thomas C.& Graf, Claudine& Biesterfeld, Stefan& Brenner, Walburgis& Schadt, Jörg& Gockel, Ines…[et al.]. 2008. Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease. Journal of Oncology،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-486210
Modern Language Association (MLA)
Wehler, Thomas C.…[et al.]. Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease. Journal of Oncology No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-486210
American Medical Association (AMA)
Wehler, Thomas C.& Graf, Claudine& Biesterfeld, Stefan& Brenner, Walburgis& Schadt, Jörg& Gockel, Ines…[et al.]. Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease. Journal of Oncology. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-486210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486210
