The Enzymatic Antioxidant System of Human Spermatozoa
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The ejaculated spermatozoon, as an aerobic cell, must fight against toxic levels of reactive oxygen species (ROS) generated by its own metabolism but also by other sources such as abnormal spermatozoa, chemicals and toxicants, or the presence of leukocytes in semen.
Mammalian spermatozoa are extremely sensitive to oxidative stress, a condition occurring when there is a net increase in ROS levels within the cell.
Opportunely, this specialized cell has a battery of antioxidant enzymes (superoxide dismutase, peroxiredoxins, thioredoxins, thioredoxins reductases, and glutathione s-transferases) working in concert to assure normal sperm function.
Any impairment of the antioxidant enzymatic activities will promote severe oxidative damage which is observed as plasma membrane lipid peroxidation, oxidation of structural proteins and enzymes, and oxidation of DNA bases that lead to abnormal sperm function.
Altogether, these damages occurring in spermatozoa are associated with male infertility.
The present review contains a description of the enzymatic antioxidant system of the human spermatozoon and a reevaluation of the role of its different components and highlights the necessity of sufficient supply of reducing agents (NADPH and reduced glutathione) to guarantee normal sperm function.
American Psychological Association (APA)
O’Flaherty, Cristian. 2014. The Enzymatic Antioxidant System of Human Spermatozoa. Advances in Andrology،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-486212
Modern Language Association (MLA)
O’Flaherty, Cristian. The Enzymatic Antioxidant System of Human Spermatozoa. Advances in Andrology No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-486212
American Medical Association (AMA)
O’Flaherty, Cristian. The Enzymatic Antioxidant System of Human Spermatozoa. Advances in Andrology. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-486212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486212