Native and Complexed IGF-1 : Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis
Joint Authors
Riikonen, Raili
Salonen, Jarno
Jalanko, Anu
Närvänen, Ale
Kaasalainen, Martti
Rytkönen, Jussi
Huhtala, Tuulia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of childhood characterized by selective death of cortical neurons.
Insulin-like growth factor 1 (IGF-1) is important in embryonic development and is considered as a potential therapeutic agent for several disorders of peripheral and central nervous systems.
In circulation IGF-1 is mainly bound to its carrier protein IGFBP-3.
As a therapeutic agent IGF-1 has shown to be more active as free than complexed form.
However, this may cause side effects during the prolonged treatment.
In addition to IGFBP-3 the bioavailability of IGF-1 can be modulated by using mesoporous silicon nanoparticles (NPs) which are optimal carriers for sustained release of unstable peptide hormones like IGF-1.
In this study we compared biodistribution, pharmacokinetics, and bioavailability of radiolabeled free IGF-1, IGF-1/IGFBP-3, and IGF-1/NP complexes in a Cln1-/- knockout mouse model.
IGF-1/NP was mainly accumulated in liver and spleen in all studied time points, whereas minor and more constant amounts were measured in other organs compared to free IGF-1 or IGF-1/IGFBP-3.
Also concentration of IGF-1/NP in blood was relatively high and stable during studied time points suggesting continuous release of IGF-1 from the particles.
American Psychological Association (APA)
Huhtala, Tuulia& Rytkönen, Jussi& Jalanko, Anu& Kaasalainen, Martti& Salonen, Jarno& Riikonen, Raili…[et al.]. 2012. Native and Complexed IGF-1 : Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486216
Modern Language Association (MLA)
Huhtala, Tuulia…[et al.]. Native and Complexed IGF-1 : Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis. Journal of Drug Delivery No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-486216
American Medical Association (AMA)
Huhtala, Tuulia& Rytkönen, Jussi& Jalanko, Anu& Kaasalainen, Martti& Salonen, Jarno& Riikonen, Raili…[et al.]. Native and Complexed IGF-1 : Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-486216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486216