Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients
Joint Authors
Soufleros, Konstantinos
Papasteriades, Chryssa
Pipi, Elena
Tsiveriotis, Konstantinos
Tsirogianni, Alexandra
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To retrospectively evaluate ANCA testing in a cohort of unselected Greek in- and outpatients.
Methods.
In 10803 consecutive serum samples, ANCA were tested by indirect immunofluorescence (IIF) and ELISA.
ELISA in inpatients was performed only on IIF positive sera.
Results.
Low prevalence (6.0%) of IIF positive samples was observed.
Among these samples, 63.5% presented perinuclear (p-ANCA), 9.3% cytoplasmic (c-ANCA) and 27.2% atypical (x-ANCA) pattern.
16.1% of p-ANCA were antimyeloperoxidase (anti-MPO) positive, whereas 68.3% of c-ANCA were antiproteinase-3 (anti-PR3) positive.
Only 17 IIF negative outpatients' samples were ELISA positive.
ANCA-associated vasculitides (AAV), connective tissue disorders and gastrointestinal disorders represented 20.5%, 23.9%, and 21.2% of positive results, respectively.
AAV patients exhibited higher rates of MPO/PR3 specificity compared to non-AAV (93.8% versus 8%).
Conclusions.
This first paper on Greek patients supports that screening for ANCA by IIF and confirming positive results by ELISA minimize laboratory charges without sacrificing diagnostic accuracy.
American Psychological Association (APA)
Tsiveriotis, Konstantinos& Tsirogianni, Alexandra& Pipi, Elena& Soufleros, Konstantinos& Papasteriades, Chryssa. 2011. Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-486220
Modern Language Association (MLA)
Tsiveriotis, Konstantinos…[et al.]. Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients. Autoimmune Diseases No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-486220
American Medical Association (AMA)
Tsiveriotis, Konstantinos& Tsirogianni, Alexandra& Pipi, Elena& Soufleros, Konstantinos& Papasteriades, Chryssa. Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-486220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486220