Robust Control of Continuous Bioprocesses

Abstract EN

This paper deals with robust control of continuous bioprocesses.

According to the material balance equations of continuous bioprocesses, a uniform framework for mathematical modeling of this class of processes is first presented.

Then a robust controller is designed by using the H∞ mixed sensitivity method for the biotechnology processes.

The corresponding control objective is described as the development of a robust reference-tracking control structure with the best possible disturbance compensation, able to cope with variations in key process parameters.

Finally, the proposed robust control strategy is applied to bio-dissimilation process of glycerol to 1, 3-propanediol.

Simulation results are given which show that the designed robust controller makes the system have a favourable robust tracking performance.