Insulin and the Lung : Connecting Asthma and Metabolic Syndrome
Joint Authors
Singh, Suchita
Prakash, Y. S.
Linneberg, Allan
Agrawal, Anurag
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Obesity, metabolic syndrome, and asthma are all rapidly increasing globally.
Substantial emerging evidence suggests that these three conditions are epidemiologically and mechanistically linked.
Since the link between obesity and asthma appears to extend beyond mechanical pulmonary disadvantage, molecular understanding is necessary.
Insulin resistance is a strong, independent risk factor for asthma development, but it is unknown whether a direct effect of insulin on the lung is involved.
This review summarizes current knowledge regarding the effect of insulin on cellular components of the lung and highlights the molecular consequences of insulin-related metabolic signaling cascades that could adversely affect lung structure and function.
Examples include airway smooth muscle proliferation and contractility and regulatory signaling networks that are associated with asthma.
These aspects of insulin signaling provide mechanistic insight into the clinical evidence for the links between obesity, metabolic syndrome, and airway diseases, setting the stage for novel therapeutic avenues targeting these conditions.
American Psychological Association (APA)
Singh, Suchita& Prakash, Y. S.& Linneberg, Allan& Agrawal, Anurag. 2013. Insulin and the Lung : Connecting Asthma and Metabolic Syndrome. Journal of Allergy،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486282
Modern Language Association (MLA)
Singh, Suchita…[et al.]. Insulin and the Lung : Connecting Asthma and Metabolic Syndrome. Journal of Allergy No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-486282
American Medical Association (AMA)
Singh, Suchita& Prakash, Y. S.& Linneberg, Allan& Agrawal, Anurag. Insulin and the Lung : Connecting Asthma and Metabolic Syndrome. Journal of Allergy. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486282