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Effectiveness of Bortezomib in Cardiac AL Amyloidosis : A Report of Two Cases
Joint Authors
Curciarello, Giuseppe
Michelassi, Stefano
Nigrelli, Santi
Ballo, Piercarlo
Pizzarelli, Francesco
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cardiac involvement is a major prognostic determinant in patients with primary AL amyloidosis.
The clinical results of standard therapeutic approaches are suboptimal.
It has been recently shown that bortezomib, an inhibitor of the proteasome, can induce rapid favourable responses in AL amyloidosis improving cardiac function and survival.
Herein we report on two patients with cardiac amyloidosis treated by bortezomib who experienced partial or total remission of hematologic disease and of cardiac involvement.
However, death of one patient, suffering from chronic kidney disease stage 5, due to fulminant respiratory syndrome suggests the need for caution in bortezomib use if patients have this comorbid condition.
American Psychological Association (APA)
Nigrelli, Santi& Curciarello, Giuseppe& Ballo, Piercarlo& Michelassi, Stefano& Pizzarelli, Francesco. 2014. Effectiveness of Bortezomib in Cardiac AL Amyloidosis : A Report of Two Cases. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-486292
Modern Language Association (MLA)
Nigrelli, Santi…[et al.]. Effectiveness of Bortezomib in Cardiac AL Amyloidosis : A Report of Two Cases. Case Reports in Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-486292
American Medical Association (AMA)
Nigrelli, Santi& Curciarello, Giuseppe& Ballo, Piercarlo& Michelassi, Stefano& Pizzarelli, Francesco. Effectiveness of Bortezomib in Cardiac AL Amyloidosis : A Report of Two Cases. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-486292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486292