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The Role of Single Nucleotide Polymorphisms in Predicting Prostate Cancer Risk and Therapeutic Decision Making
Joint Authors
Clinckemalie, Liesbeth
Helsen, Christine
Claessens, Frank
Joniau, Steven
Spans, Lien
Van Poppel, Hendrik
Prekovic, Stefan
Van den Broeck, Thomas
Tosco, Lorenzo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Prostate cancer (PCa) is a major health care problem because of its high prevalence, health-related costs, and mortality.
Epidemiological studies have suggested an important role of genetics in PCa development.
Because of this, an increasing number of single nucleotide polymorphisms (SNPs) had been suggested to be implicated in the development and progression of PCa.
While individual SNPs are only moderately associated with PCa risk, in combination, they have a stronger, dose-dependent association, currently explaining 30% of PCa familial risk.
This review aims to give a brief overview of studies in which the possible role of genetic variants was investigated in clinical settings.
We will highlight the major research questions in the translation of SNP identification into clinical practice.
American Psychological Association (APA)
Van den Broeck, Thomas& Joniau, Steven& Clinckemalie, Liesbeth& Helsen, Christine& Prekovic, Stefan& Spans, Lien…[et al.]. 2014. The Role of Single Nucleotide Polymorphisms in Predicting Prostate Cancer Risk and Therapeutic Decision Making. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-486296
Modern Language Association (MLA)
Van den Broeck, Thomas…[et al.]. The Role of Single Nucleotide Polymorphisms in Predicting Prostate Cancer Risk and Therapeutic Decision Making. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-486296
American Medical Association (AMA)
Van den Broeck, Thomas& Joniau, Steven& Clinckemalie, Liesbeth& Helsen, Christine& Prekovic, Stefan& Spans, Lien…[et al.]. The Role of Single Nucleotide Polymorphisms in Predicting Prostate Cancer Risk and Therapeutic Decision Making. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-486296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486296