The Tousled-Like Kinases as Guardians of Genome Integrity
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The Tousled-like kinases (TLKs) function in processes of chromatin assembly, including replication, transcription, repair, and chromosome segregation.
TLKs interact specifically (and phosphorylate) with the chromatin assembly factor Asf1, a histone H3-H4 chaperone, histone H3 itself at Ser10, and also Rad9, a key protein involved in DNA repair and cell cycle signaling following DNA damage.
These interactions are believed to be responsible for the action of TLKs in double-stranded break repair and radioprotection and also in the propagation of the DNA damage response.
Hence, I propose that TLKs play key roles in maintenance of genome integrity in many organisms of both kingdoms.
In this paper, I highlight key issues of the known roles of these proteins, particularly in the context of DNA repair (IR and UV), their possible relevance to genome integrity and cancer development, and as possible targets for intervention in cancer management.
American Psychological Association (APA)
De Benedetti, Arrigo. 2012. The Tousled-Like Kinases as Guardians of Genome Integrity. ISRN Molecular Biology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486305
Modern Language Association (MLA)
De Benedetti, Arrigo. The Tousled-Like Kinases as Guardians of Genome Integrity. ISRN Molecular Biology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-486305
American Medical Association (AMA)
De Benedetti, Arrigo. The Tousled-Like Kinases as Guardians of Genome Integrity. ISRN Molecular Biology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-486305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486305