Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology
Joint Authors
Dey, Sanjay
Pramanik, Soumen
Malgope, Ananya
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere.
A 32 full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X1) and stirring speed (X2), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release.
The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm.
The drug release was also sustained for more than 12 hours.
The study helped in finding the optimum formulation with excellent sustained drug release.
American Psychological Association (APA)
Dey, Sanjay& Pramanik, Soumen& Malgope, Ananya. 2011. Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486308
Modern Language Association (MLA)
Dey, Sanjay…[et al.]. Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology. ISRN Pharmaceutics No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-486308
American Medical Association (AMA)
Dey, Sanjay& Pramanik, Soumen& Malgope, Ananya. Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486308
