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Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
Joint Authors
Xianbao, Liu
Chunfang, Zhang
Xu, Zeng
Dunjin, Chen
Hong, Zhan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Dexmedetomidine (DEX) is an α2-adrenergic agonist.
It decreases the levels of norepinephrine release, resulting in a reduction of postsynaptic adrenergic activity.
In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats in which BMODS was induced by the combination of hypotension and clamping of the superior mesenteric artery.
We evaluated the role of dexmedetomidine (DEX) in cytokine release during postpartum BMODS in rats.
In summary, the present study demonstrated that DEX administration reduced IFN-r and IL-4 release and decreased lung injury during postpartum BMODS.
It is possible that DEX administration decreased inflammatory cytokine production in BMODS by inhibiting inflammation and free radical release by leukocytes independent of the DEX dose.
American Psychological Association (APA)
Xianbao, Liu& Hong, Zhan& Xu, Zeng& Chunfang, Zhang& Dunjin, Chen. 2013. Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486314
Modern Language Association (MLA)
Xianbao, Liu…[et al.]. Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-486314
American Medical Association (AMA)
Xianbao, Liu& Hong, Zhan& Xu, Zeng& Chunfang, Zhang& Dunjin, Chen. Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486314