Square Wave Voltammetric Determination of 2-Thiouracil in Pharmaceuticals and Real Samples Using Glassy Carbon Electrode

Abstract EN

A simple and rapid method was developed using cyclic and square wave voltammetric techniques for the determination of trace-level sulfur containing compound, 2-thiouracil, at a glassy carbon electrode.

2-thiouracil produced two anodic peaks at 0.334 V and 1.421 V and a cathodic peak at −0.534 V.

The square wave voltammetry of 2-thiouracil gave a good linear response in the range of 1–20 μM with a detection limit of 0.16 μM and quantification limit of 0.53 μM (0.0679 μg/g), which is in good agreement as per IUPAC definition of trace component analysis (100 μg/g).

The obtained recoveries range from 98.10% to 102.1%.

The proposed method was used successfully for its quantitative determination in pharmaceutical formulations and urine as real samples.