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Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction?
Joint Authors
Trivedi, Madhukar H.
Grannemann, Bruce D.
Sunderajan, Prabha
Kurian, Benji T.
Greer, Tracy L.
Source
Depression Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Introduction.
Cognitive deficits are commonly reported by patients with major depressive disorder (MDD).
Duloxetine, a dual serotonin/noradrenaline reuptake inhibitor, may improve cognitive deficits in MDD.
It is unclear if cognitive improvements occur independently of antidepressant effects with standard antidepressant medications.
Methods.
Thirty participants with MDD who endorsed cognitive deficits at screening received 12-week duloxetine treatment.
Twenty-one participants completed treatment and baseline and posttreatment cognitive testing.
The Cambridge Neuropsychological Test Automated Battery was used to assess the following cognitive domains: attention, visual memory, executive function/set shifting and working memory, executive function/spatial planning, decision making and response control, and verbal learning and memory.
Results.
Completers showed significant cognitive improvements across several domains on tasks assessing psychomotor function and mental processing speed, with additional improvements in visual and verbal learning and memory, and affective decision making and response control.
Overall significance tests for executive function tasks were also significant, although individual tasks were not, perhaps due to the small sample size.
Most notably, cognitive improvements were observed independently of symptom reduction on all domains except verbal learning and memory.
Conclusions.
Patients reporting baseline cognitive deficits achieved cognitive improvements with duloxetine treatment, most of which were independent of symptomatic improvement.
This trial is registered with NCT00933439.
American Psychological Association (APA)
Greer, Tracy L.& Sunderajan, Prabha& Grannemann, Bruce D.& Kurian, Benji T.& Trivedi, Madhukar H.. 2014. Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction?. Depression Research and Treatment،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-486320
Modern Language Association (MLA)
Greer, Tracy L.…[et al.]. Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction?. Depression Research and Treatment No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-486320
American Medical Association (AMA)
Greer, Tracy L.& Sunderajan, Prabha& Grannemann, Bruce D.& Kurian, Benji T.& Trivedi, Madhukar H.. Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction?. Depression Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-486320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486320