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Efficacy of Telmisartan Plus Amlodipine in Nonresponders to CCB Monotherapy
Joint Authors
Neldam, Steen
Schumacher, Helmut
Zhu, Dingliang
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hypertensive patients unable to reach blood pressure (BP) targets with antihypertensive monotherapy may be switched to a combination of two medications with complementary modes of action for improved treatment response.
This post hoc analysis pools data from 2812 patients, 1891 of whom were not at goal (diastolic BP [DBP] <90 mm Hg) with amlodipine 5 mg (A5) monotherapy who subsequently switched to telmisartan 40 or 80 mg (T80)/A5 single-pill combination (SPC) or amlodipine 10 mg (A10) monotherapy, and considers an additional 921 patients, 616 of whom were not at goal with A10 monotherapy who switched to telmisartan/amlodipine SPC.
Patients switched to telmisartan/amlodipine SPC achieved significantly greater BP reductions compared with continued monotherapy (P<0.0001) with reductions of −15.2/−10.9 mm Hg seen with T80/A5 after 8 weeks in patients switched from A5.
BP goal (<140/90 mm Hg), systolic BP goal (<140 mm Hg), and DBP goal (<90 mm Hg) were reached by significantly more patients with telmisartan/amlodipine than with monotherapy (P<0.0001 for all comparisons; 56.1%, 69.7%, and 66.9%, resp., in patients who switched from A5 to T80/A5).
Early use of such combination therapy should be considered to quickly reach BP targets, particularly in patients with added risk.
American Psychological Association (APA)
Neldam, Steen& Zhu, Dingliang& Schumacher, Helmut. 2013. Efficacy of Telmisartan Plus Amlodipine in Nonresponders to CCB Monotherapy. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486329
Modern Language Association (MLA)
Neldam, Steen…[et al.]. Efficacy of Telmisartan Plus Amlodipine in Nonresponders to CCB Monotherapy. International Journal of Hypertension No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-486329
American Medical Association (AMA)
Neldam, Steen& Zhu, Dingliang& Schumacher, Helmut. Efficacy of Telmisartan Plus Amlodipine in Nonresponders to CCB Monotherapy. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486329