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Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease : An Inventory of the Available Data
Joint Authors
Sette, Alessandro
Goodman, Richard
Grey, Howard
Peters, Bjoern
Kim, Yohan
Vaughan, Kerrie
Vita, Randi
Greenbaum, Jason
Broide, David
Chung, Jo
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals.
Herein a meta-analysis was performed on allergy-related data from the immune epitope database (IEDB) to provide a current inventory and highlight knowledge gaps and areas for future work.
The analysis identified over 4,500 allergy-related epitopes derived from 270 different allergens.
Overall, the distribution of the data followed expectations based on the nature of allergic responses.
Namely, the majority of epitopes were defined for B cells/antibodies and IgE-mediated reactivity, and relatively fewer T-cell epitopes, mostly CD4+/class II.
Interestingly, the majority of food allergen epitopes were B-cells epitopes whereas a fairly even number of B- and T-cell epitopes were defined for airborne allergens.
In addition, epitopes from nonhumans hosts were mostly T-cell epitopes.
Overall, coverage of known allergens is sparse with data available for only ~17% of all allergens listed by the IUIS database.
Thus, further research would be required to provide a more balanced representation across different allergen categories.
Furthermore, inclusion of nonpeptidic epitopes in the IEDB also allows for inventory and analysis of immunological data associated with drug and contact allergen epitopes.
Finally, our analysis also underscores that only a handful of epitopes have thus far been investigated for their immunotherapeutic potential.
American Psychological Association (APA)
Vaughan, Kerrie& Greenbaum, Jason& Kim, Yohan& Vita, Randi& Chung, Jo& Peters, Bjoern…[et al.]. 2011. Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease : An Inventory of the Available Data. Journal of Allergy،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-486340
Modern Language Association (MLA)
Vaughan, Kerrie…[et al.]. Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease : An Inventory of the Available Data. Journal of Allergy No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-486340
American Medical Association (AMA)
Vaughan, Kerrie& Greenbaum, Jason& Kim, Yohan& Vita, Randi& Chung, Jo& Peters, Bjoern…[et al.]. Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease : An Inventory of the Available Data. Journal of Allergy. 2011. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-486340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486340