Clear Cell Cancer of the Uterine Corpus : The Association of Clinicopathologic Parameters and Treatment on Disease Progression

Abstract EN

This paper presents a single-institution experience regarding the clinicopathologic features and treatment strategies used in uterine clear cell cancer (UCC), a rare, aggressive histologic subtype of uterine cancer with poor prognosis and discusses parameters associated with progression-free survival (PFS) and overall survival (OS).

A retrospective chart review was performed on all patients (n=80) diagnosed with UCC and treated between 1994 and 2009 at a single academic institution.

Data on demographics, FIGO stage, treatment regimens, and recurrences were collected.

Patients with early-stage UCC had an excellent survival regardless of adjuvant therapy.

Advanced-stage patients had a worse survival.

Vaginal apex brachytherapy was associated with an increased OS (P=0.02) but not PFS (P=0.10).

The use of platinum-based chemotherapy in combination with vaginal apex brachytherapy did not significantly improve survival.

Innovative therapies still need to be identified for this uncommon uterine cancer.