![](/images/graphics-bg.png)
Can Ki-67 Play a Role in Prediction of Breast Cancer Patients' Response to Neoadjuvant Chemotherapy?
Joint Authors
Gilda, Schmidt
Andrea, Hasenfus
Russalina, Mavrova
Daniel, Herr
Erich, Solomayer
Ingolf, Juhasz-Böss
Simona, Moga
Bohle, Rainer M.
Julia, Radosa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Currently the choice of breast cancer therapy is based on prognostic factors.
The proliferation marker Ki-67 is used increasingly to determine the method of therapy.
The current study analyses the predictive value of Ki-67 in foreseeing breast cancer patients’ responses to neoadjuvant chemotherapy.
Methods.
This study includes patients with invasive breast cancer treated between 2008 and 2013.
The clinical response was assessed by correlating Ki-67 to histological examination, mammography, and ultrasonography findings.
Results.
The average Ki-67 value in our patients collectively (n=77) is 34.9 ± 24.6%.
The average Ki-67 value is the highest with 37.4 ± 24.0% in patients with a pCR.
The Ki-67 values do not differ significantly among the 3 groups: pCR versus partial pathological response versus stable disease/progress (P=0.896).
However, Ki-67 values of patients with luminal, Her2 enriched, and basal-like cancers differed significantly from each other.
Furthermore, within the group of luminal tumors Ki-67 values of patients with versus without pCR also differed significantly.
Conclusion.
Our data shows that the Ki-67 value predicts the response to neoadjuvant chemotherapy as a function of the molecular subtype, reflecting the daily routine concerning Ki-67 and its impressing potential and limitation as a predictive marker for neoadjuvant chemotherapy response.
American Psychological Association (APA)
Ingolf, Juhasz-Böss& Russalina, Mavrova& Simona, Moga& Julia, Radosa& Gilda, Schmidt& Bohle, Rainer M.…[et al.]. 2014. Can Ki-67 Play a Role in Prediction of Breast Cancer Patients' Response to Neoadjuvant Chemotherapy?. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486365
Modern Language Association (MLA)
Ingolf, Juhasz-Böss…[et al.]. Can Ki-67 Play a Role in Prediction of Breast Cancer Patients' Response to Neoadjuvant Chemotherapy?. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-486365
American Medical Association (AMA)
Ingolf, Juhasz-Böss& Russalina, Mavrova& Simona, Moga& Julia, Radosa& Gilda, Schmidt& Bohle, Rainer M.…[et al.]. Can Ki-67 Play a Role in Prediction of Breast Cancer Patients' Response to Neoadjuvant Chemotherapy?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-486365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486365