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A Simple and Advantageous Synthesis of the Privileged 1,4-Benzodiazepine Nucleus
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A novel domino approach has been described for an easy access of the privileged nucleus of 5-carbomethoxy substituted 1,4-benzodiazepin-2-ones 4(a–i) from an in situ methanolic hydrolysis of an incipient species formed from the interaction of 1-chloroacetylisatin 2(a–i), hexamethyldisilazane, and n-butyl lithium.
The reaction is believed to take place through a consecutive series of intramolecular reactions in a cascade to first generate a highly reactive carbene intermediate 3(a–i) from 1-chloroacetylisatin and n-butyl lithium which is simultaneously trapped by hexamethyldisilazane before undergoing its in situ hydrolysis with methanol to initiate its concomitant cyclocondensation to produce 4(a–i) in high yield and purity.
American Psychological Association (APA)
Jain, Neetu& Kishore, Dharma. 2014. A Simple and Advantageous Synthesis of the Privileged 1,4-Benzodiazepine Nucleus. Advances in Chemistry،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-486378
Modern Language Association (MLA)
Jain, Neetu& Kishore, Dharma. A Simple and Advantageous Synthesis of the Privileged 1,4-Benzodiazepine Nucleus. Advances in Chemistry No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-486378
American Medical Association (AMA)
Jain, Neetu& Kishore, Dharma. A Simple and Advantageous Synthesis of the Privileged 1,4-Benzodiazepine Nucleus. Advances in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-486378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486378