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Dengue Virus Entry as Target for Antiviral Therapy
Joint Authors
Alen, Marijke M. F.
Schols, Dominique
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dengue virus (DENV) infections are expanding worldwide and, because of the lack of a vaccine, the search for antiviral products is imperative.
Four serotypes of DENV are described and they all cause a similar disease outcome.
It would be interesting to develop an antiviral product that can interact with all four serotypes, prevent host cell infection and subsequent immune activation.
DENV entry is thus an interesting target for antiviral therapy.
DENV enters the host cell through receptor-mediated endocytosis.
Several cellular receptors have been proposed, and DC-SIGN, present on dendritic cells, is considered as the most important DENV receptor until now.
Because DENV entry is a target for antiviral therapy, various classes of compounds have been investigated to inhibit this process.
In this paper, an overview is given of all the putative DENV receptors, and the most promising DENV entry inhibitors are discussed.
American Psychological Association (APA)
Alen, Marijke M. F.& Schols, Dominique. 2012. Dengue Virus Entry as Target for Antiviral Therapy. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-486391
Modern Language Association (MLA)
Alen, Marijke M. F.& Schols, Dominique. Dengue Virus Entry as Target for Antiviral Therapy. Journal of Tropical Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-486391
American Medical Association (AMA)
Alen, Marijke M. F.& Schols, Dominique. Dengue Virus Entry as Target for Antiviral Therapy. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-486391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486391