![](/images/graphics-bg.png)
Thiazolidinedione-Induced Fluid Retention : Recent Insights into the Molecular Mechanisms
Joint Authors
Włodarczyk, Mirosław
Rachańczyk, Jolanta
Bełtowski, Jerzy
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPARγ) agonists such as rosiglitazone and pioglitazone are used to improve insulin sensitivity in patients with diabetes mellitus.
However, thiazolidinediones induce fluid retention, edema, and sometimes precipitate or exacerbate heart failure in a subset of patients.
The mechanism through which thiazolidinediones induce fluid retention is controversial.
Most studies suggest that this effect results from the increase in tubular sodium and water reabsorption in the kidney, but the role of specific nephron segments and sodium carriers involved is less clear.
Some studies suggested that PPARγ agonist stimulates Na+ reabsorption in the collecting duct by activating epithelial Na+ channel (ENaC), either directly or through serum and glucocorticoid-regulated kinase-1 (SGK-1).
However, other studies did not confirm this mechanism and even report the suppression of ENaC.
Alternative mechanisms in the collecting duct include stimulation of non-ENaC sodium channel or inhibition of chloride secretion to the tubular lumen.
In addition, thiazolidinediones may augment sodium reabsorption in the proximal tubule by stimulating the expression and activity of apical Na+/H+ exchanger-3 and basolateral Na+-HCO3 − cotransporter as well as of Na+,K+-ATPase.
These effects are mediated by PPARγ-induced nongenomic transactivation of the epidermal growth factor receptor and downstream extracellular signal-regulated kinases (ERK).
American Psychological Association (APA)
Bełtowski, Jerzy& Rachańczyk, Jolanta& Włodarczyk, Mirosław. 2013. Thiazolidinedione-Induced Fluid Retention : Recent Insights into the Molecular Mechanisms. PPAR Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486408
Modern Language Association (MLA)
Bełtowski, Jerzy…[et al.]. Thiazolidinedione-Induced Fluid Retention : Recent Insights into the Molecular Mechanisms. PPAR Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-486408
American Medical Association (AMA)
Bełtowski, Jerzy& Rachańczyk, Jolanta& Włodarczyk, Mirosław. Thiazolidinedione-Induced Fluid Retention : Recent Insights into the Molecular Mechanisms. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-486408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486408