A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect
Joint Authors
Su, Wu-Chou
Wang, Ae-June
Liang, Hsiang-Fa
Tsao, Chih-Wan
Kan, Pei
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A liposome formulation for paclitaxel was developed in this study.
The liposomes, composed of naturally unsaturated and hydrogenated phosphatidylcholines, with significant phase transition temperature difference, were prepared and characterized.
The liposomes exhibited a high content of paclitaxel, which was incorporated within the segregated microdomains coexisting on phospholipid bilayer of liposomes.
As much as 15% paclitaxel to phospholipid molar ratio were attained without precipitates observed during preparation.
In addition, the liposomes remained stable in liquid form at 4∘C for at least 6 months.
The special composition of liposomal membrane which could reduce paclitaxel aggregation could account for such a capacity and stability.
The cytotoxicity of prepared paclitaxel liposomes on the colon cancer C-26 cell culture was comparable to Taxol.
Acute toxicity test revealed that LD50 for intravenous bolus injection in mice exceeded by 40 mg/kg.
In antitumor efficacy study, the prepared liposomal paclitaxel demonstrated the increase in the efficacy against human cancer in animal model.
Taken together, the novel formulated liposomes can incorporate high content of paclitaxel, remaining stable for long-term storage.
These animal data also demonstrate that the liposomal paclitaxel is promising for further clinical use.
American Psychological Association (APA)
Kan, Pei& Tsao, Chih-Wan& Wang, Ae-June& Su, Wu-Chou& Liang, Hsiang-Fa. 2010. A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-486461
Modern Language Association (MLA)
Kan, Pei…[et al.]. A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect. Journal of Drug Delivery No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-486461
American Medical Association (AMA)
Kan, Pei& Tsao, Chih-Wan& Wang, Ae-June& Su, Wu-Chou& Liang, Hsiang-Fa. A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect. Journal of Drug Delivery. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-486461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486461