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Rapid Infusion Rituximab for Maintenance Therapy : Is It Feasible?
Joint Authors
Sokol, Lubomir
Wetzstein, Gene
Ho, Viet
Djulbegovic, Benjamin
Bello, Celeste
Patel, Jolly
Ho, Melissa
Source
Leukemia Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Rituximab is an anti-CD-20 monoclonal antibody used in the management of lymphoproliferative disorders.
The use of maintenance rituximab has improved progression free survival and overall survival in follicular lymphomas.
Although rapid rituximab infusions have been studied extensively, there is little data on the use of rapid infusions during maintenance therapy for low grade lymphomas.
The primary objective of this retrospective analysis was to evaluate the incidence of Grade 3 and 4 toxicities with maintenance rapid infusion rituximab according to the Common Terminology Criteria for Adverse Events version 4 (CTC v.
4).
Secondary objectives included evaluating all grade infusion related adverse events and correlation of adverse events with varying schedules of rituximab maintenance therapy.
All patients who received rapid infusion rituximab as maintenance therapy for low grade lymphoma between December 2007 and November 2011 were included.
Rapid rituximab infusions were administered over 90 minutes.
Demographic, laboratory and clinical data were collected.
A total of 109 patients received 647 rapid rituximab infusions.
Three patients experienced an adverse reaction which resulted in one grade 1 infusion reaction and three grade 3 infusion reactions.
No patients required hospitalization.
All 3 patients received pharmacological and/or supportive care to relieve symptoms associated with the reaction.
American Psychological Association (APA)
Patel, Jolly& Ho, Melissa& Ho, Viet& Bello, Celeste& Djulbegovic, Benjamin& Sokol, Lubomir…[et al.]. 2013. Rapid Infusion Rituximab for Maintenance Therapy : Is It Feasible?. Leukemia Research and Treatment،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-486466
Modern Language Association (MLA)
Patel, Jolly…[et al.]. Rapid Infusion Rituximab for Maintenance Therapy : Is It Feasible?. Leukemia Research and Treatment No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-486466
American Medical Association (AMA)
Patel, Jolly& Ho, Melissa& Ho, Viet& Bello, Celeste& Djulbegovic, Benjamin& Sokol, Lubomir…[et al.]. Rapid Infusion Rituximab for Maintenance Therapy : Is It Feasible?. Leukemia Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-486466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486466