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Silicate Urolithiasis during Long-Term Treatment with Zonisamide
Joint Authors
Kobayashi, Teruaki
Taguchi, Satoru
Nose, Yorito
Homma, Yukio
Ishikawa, Akira
Takaya, Kanami
Sato, Toshikazu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-02
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Silicate urinary calculi are rare in humans, with an incidence of 0.2% of all urinary calculi.
Most cases were related to excess ingestion of silicate, typically by taking magnesium trisilicate as an antacid for peptic ulcers over a long period of time; however, there also existed unrelated cases, whose mechanism of development remains unclear.
On the other hand, zonisamide, a newer antiepileptic drug, is one of the important causing agents of iatrogenic urinary stones in patients with epilepsy.
The supposed mechanism is that zonisamide induces urine alkalinization and then promotes crystallization of urine components such as calcium phosphate by inhibition of carbonate dehydratase in renal tubular epithelial cells.
Here, we report a case of silicate urolithiasis during long-term treatment with zonisamide without magnesium trisilicate intake and discuss the etiology of the disease by examining the silicate concentration in his urine.
American Psychological Association (APA)
Taguchi, Satoru& Nose, Yorito& Sato, Toshikazu& Kobayashi, Teruaki& Takaya, Kanami& Ishikawa, Akira…[et al.]. 2013. Silicate Urolithiasis during Long-Term Treatment with Zonisamide. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-486478
Modern Language Association (MLA)
Taguchi, Satoru…[et al.]. Silicate Urolithiasis during Long-Term Treatment with Zonisamide. Case Reports in Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-486478
American Medical Association (AMA)
Taguchi, Satoru& Nose, Yorito& Sato, Toshikazu& Kobayashi, Teruaki& Takaya, Kanami& Ishikawa, Akira…[et al.]. Silicate Urolithiasis during Long-Term Treatment with Zonisamide. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-486478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486478