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TNF-Alpha Levels in Tears : A Novel Biomarker to Assess the Degree of Diabetic Retinopathy
Joint Authors
Romano, Mario R.
Semeraro, Francesco
Pedicino, C.
Romano, Vito
Aceto, F.
De Tollis, M.
dell'Omo, Roberto
Costagliola, Ciro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We assess the level of tumour necrosis factor alpha (TNF-alpha) in tear fluids and other serum parameters associated with diabetes in different degrees of diabetic retinopathy.
We have performed a prospective, nonrandomized, observational study.
Study population consisted of 16 healthy subjects (controls) and 32 type 2 diabetic patients: 16 affected by proliferative diabetic retinopathy (PDR) and 16 with nonproliferative retinopathy (NDPR, background/preproliferative).
Body mass index, urinary albumin, blood glucose, HbA1c, and tear levels of TNF-alpha were measured in all subjects.
The value of glycaemia, microalbuminurea, and Body mass index in diabetic retinopathy groups were higher than those in control group (P<0.05).
Glycemia in NPDR: 6.6 mmol/L (range: 5.8–6.3); in PDR: 6.7 mmol/L (range: 6.1–7.2); in control: 5.7 mmol/L (range: 4.9–6.1); microalbuminurea in NPDR: 10.6 mg/L (range: 5.6–20); in PDR: 25.2 mg/L (range: 17–40); in control: 5.3 mg/L (range: 2.6–10); Body mass index in NPDR: 26 Kg/m2 (range: 20.3–40); in PDR: 28 Kg/m2 (range 20.3–52); in control: 21 Kg/m2 (range 19–26).
The TNF-alpha concentrations in tears increase with the severity of pathology and were lower in control group than in diabetic subjects.
In the end, the level of TNF-alpha is highly correlated with severity of diabetic retinopathy and with nephropathy.
Tear fluid collection may be a useful noninvasive method for the detection of proliferative diabetic retinopathy.
American Psychological Association (APA)
Costagliola, Ciro& Romano, Vito& De Tollis, M.& Aceto, F.& dell'Omo, Roberto& Romano, Mario R.…[et al.]. 2013. TNF-Alpha Levels in Tears : A Novel Biomarker to Assess the Degree of Diabetic Retinopathy. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-486493
Modern Language Association (MLA)
Costagliola, Ciro…[et al.]. TNF-Alpha Levels in Tears : A Novel Biomarker to Assess the Degree of Diabetic Retinopathy. Mediators of Inflammation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-486493
American Medical Association (AMA)
Costagliola, Ciro& Romano, Vito& De Tollis, M.& Aceto, F.& dell'Omo, Roberto& Romano, Mario R.…[et al.]. TNF-Alpha Levels in Tears : A Novel Biomarker to Assess the Degree of Diabetic Retinopathy. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-486493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486493