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In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex
Joint Authors
Mostafa, Mohamed
Nasr, Mohamed
Shaker, Mahmoud
Hashem, Fahima M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The objective of this study was to evaluate the influence of oxatomide β-cyclodextrin inclusion complex on the physicochemical properties and bioavailability of the drug.
Oxatomide β-cyclodextrin solid complex was prepared with equimolar ratio of both oxatomide and β-cyclodextrin in presence or absence of water soluble polymers using different techniques.
The coevaporated complex prepared in presence of PVP-K15 showed a prompt drug release and significantly increased % dissolution efficiency (P<0.05) compared to the pure oxatomide.
Moreover, the results of bioavailability evaluation of this complex in rabbits compared to commercial drug product indicated a 73.15% increase in the oral bioavailability of oxatomide.
In conclusion, inclusion complex of oxatomide with β-cyclodextrin prepared by coevaporation in presence of PVP-K15 not only results in an enhancement of the oxatomide dissolution rate but also improves the bioavailability of oxatomide.
American Psychological Association (APA)
Hashem, Fahima M.& Mostafa, Mohamed& Shaker, Mahmoud& Nasr, Mohamed. 2012. In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486499
Modern Language Association (MLA)
Hashem, Fahima M.…[et al.]. In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex. Journal of Pharmaceutics No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-486499
American Medical Association (AMA)
Hashem, Fahima M.& Mostafa, Mohamed& Shaker, Mahmoud& Nasr, Mohamed. In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex. Journal of Pharmaceutics. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-486499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486499