Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats
Joint Authors
Eklund, C. R.
Evans, Marina V.
Janes, T. A. T.
Cuello, W. S.
Venecek, M. A.
Jessee, J. M.
Sawyer, M. E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Bromochloromethane (BCM) is a volatile compound and a by-product of disinfection of water by chlorination.
Physiologically based pharmacokinetic (PBPK) models are used in risk assessment applications.
An updated PBPK model for BCM is generated and applied to hypotheses testing calibrated using vapor uptake data.
The two different metabolic hypotheses examined are (1) a two-pathway model using both CYP2E1 and glutathione transferase enzymes and (2) a two-binding site model where metabolism can occur on one enzyme, CYP2E1.
Our computer simulations show that both hypotheses describe the experimental data in a similar manner.
The two pathway results were comparable to previously reported values (Vmax=3.8 mg/hour, Km=0.35 mg/liter, and kGST=4.7 /hour).
The two binding site results were Vmax1=3.7 mg/hour, Km1=0.3 mg/hour, CL2 = 0.047 liter/hour.
In addition, we explore the sensitivity of different parameters for each model using our obtained optimized values.
American Psychological Association (APA)
Cuello, W. S.& Janes, T. A. T.& Jessee, J. M.& Venecek, M. A.& Sawyer, M. E.& Eklund, C. R.…[et al.]. 2012. Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-486520
Modern Language Association (MLA)
Cuello, W. S.…[et al.]. Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats. Journal of Toxicology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-486520
American Medical Association (AMA)
Cuello, W. S.& Janes, T. A. T.& Jessee, J. M.& Venecek, M. A.& Sawyer, M. E.& Eklund, C. R.…[et al.]. Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-486520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486520