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Case Report of Undifferentiated Endometrial Sarcoma in Association with Osteoclast-Like Giant Cells
Joint Authors
Kirtesh, Patel
Bardarov, Svetoslav
Khachaturov, Vadim
Jimenez, Elpidio
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We describe the clinical, gross and microscopic features of undifferentiated uterine stromal sarcoma associated with osteoclast-like giant cells.
A case of low-grade endometrial stromal sarcoma is already described in association with osteoclast-like giant cells; however, the current case differs in that the tumor was a high grade and did not show any evidence of smooth muscle or epithelioid differentiation and was shown to be strongly positive for CD10 and focally for WT-1 and Inhibin supporting an endometrial stromal origin.
The associated osteoclast-like giant cells were abundant, evenly distributed within the tumor and showed strong positivity for CD68.
Interestingly, rare (less than 2%) giant cells also showed weak cytoplasmic positivity for b-hCG.
The tumor infiltrated deep into the myometrium and had marked lymphovascular invasion.
Although the regional lymph nodes and peritoneal washings were negative, the lesion showed a highly aggressive clinical course.
Despite treatment, the tumor disseminated within the abdominal cavity and lungs and ultimately led to the patient's demise within 9 months of the diagnosis.
American Psychological Association (APA)
Bardarov, Svetoslav& Khachaturov, Vadim& Kirtesh, Patel& Jimenez, Elpidio. 2011. Case Report of Undifferentiated Endometrial Sarcoma in Association with Osteoclast-Like Giant Cells. Pathology Research International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-486524
Modern Language Association (MLA)
Bardarov, Svetoslav…[et al.]. Case Report of Undifferentiated Endometrial Sarcoma in Association with Osteoclast-Like Giant Cells. Pathology Research International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-486524
American Medical Association (AMA)
Bardarov, Svetoslav& Khachaturov, Vadim& Kirtesh, Patel& Jimenez, Elpidio. Case Report of Undifferentiated Endometrial Sarcoma in Association with Osteoclast-Like Giant Cells. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-486524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486524